Nitrone spin-traps block calcium channels and induce pulmonary artery relaxation independent of free radicals

Free radicals react with nitrones to form stable nitroxides which can be identified by ESR spectroscopy. Unfortunately, little is known regarding the pharmacological properties of these compounds. In this study, three commonly used nitrones, 5,5-dimethylpyrroline-N-oxide (DMPO), alpha-phenyl-tert-butylnitrone (PBN), and alpha-(4-pyridyl 1-oxide)-N-tert-butylnitrone (POBN), were found to induce relaxation of preconstricted isolated rat pulmonary artery rings. Additional experiments with PBN indicated that vasorelaxation could not be attributed to production of endothelial derived factors, prostaglandins, or free radicals. Patch-clamp techniques revealed reversible calcium channel blockade with PBN at a concentration below that needed to detect free radicals. Calcium channel blockade probably accounts for the vasorelaxation observed in the isolated ring preparations described here, and should be considered when using nitrone spin-traps both in in vivo and clinical studies.     

天津钢管公司DRC直接还原厂生产工艺与自动控制

天津钢管公司DRC直接还原厂将采用英国戴维国际工程公司的DRC煤基直接还原技术,以铁矿石、煤、石灰石为原燃料,用回转窑来生产直接还原铁(DRI)。该厂将由两条回转窑生产线组成,每条生产线的生产能力为15万tDRI/年,回转窑规格为φ5.0m×80m。工厂生产主线将采用计算机集散控制系统(DCS)以实现对生产过程的自动控制。     

语音时域分割研究

在语音时域挑选剩余可懂度低的可用置换集合,置换集合是语音TDS系统中不可缺少的重要环节,本文给出了可用置换选取的条件、客观评价标准和方法。     

Prescheduling policy for real-time concurrency control: A performance evaluation

A new priority management policy, aprescheduling policy, is proposed. This policy can be applied on any conventional concurrency control protocol to schedule a real-time transaction. Costly preemption is avoided by the prescheduling policy, and parsing dataset of a transaction is not needed. Three widely used conventional concurrency control protocols (dynamic two-phase locking, basic timestamp ordering, and optimistic) are incorporated with the prescheduling policy to form three real-time concurrency control protocols. Performance of the three protocols is evaluated from three different viewpoints: database management systems, protocols, and transaction. From a database management system viewpoint, we show the prescheduling policy can improve the performance of protocols by raising thevalid ratio and reducingrestart counts. In general, two-phase locking with the prescheduling policy performs the best in most cases and yields the best choice for concurrency control in a real-time application. Deciding factors that affect performance of each protocol are identified from protocol viewpoint. Some suggestions are given for writing a timely transaction from the aspect of transaction viewpoint.     

局部缺陷对旋转壳内力分布的影响

本文应用有初始几何缺陷的壳体非线性应变分量公式及内时本构理论，对冷却塔在重力作用下的内力进行了弹塑性大变形计算，分析了常见的几种缺陷对冷却塔内力分布的影响。对于工程实际中有缺陷的冷却塔的整体性能分析具有重要意义，可以为工程设计提供理论基础。     

Pore size control of porous silica by sol-gel process

Porous silica glass was prepared by sol-gel process from tetraethoxysilane (TEOS). The effects of solvents (water, ethanol), drying condition, heat treatment temperature on specific surface area and pore size distribution of porous silica were investigated. Gelation process accelerates with an increase of H₂O content, while retards with the increase of ethanol amount. Structure changes during heat treatment were studied by means of DTA, XRD. TEM micrographs show that the gel particles shrink after heated at 500°C, thus the average pore size decreases.     

Finite Element Analysis of a Moving Boundary Value Problem

A finite element formulation and the solution of a set of nonlinear coupled heat and mass transfer equations for a two-phase system with a moving evaporation interface is presented. The interface condition takes into account the moisture transfer balance at the moving boundary. The finite element results were compared with existing results for a single phase system for model validation. In the two-phase system, the movement of evaporation front has an appreciable effect on the temperature and moisture distribution inside the porous medium during drying. The effect of the nondimensional heat of vapourization parameter γ on the evaporation front, temperature and moisture distribution in porous medium was studied. The higher the value of γ, the slower is the movement of the evaporation front. The temperature decreased and the moisture content increased as the nondimensional vapourization parameter γ increased. This model has potential applications in studying the heat and mass transfer characteristics in food and biomaterials.     

Dynamic oxide voltage relaxation spectroscopy

A new method for trap characterization of oxidized silicon is described. The Dynamic Oxide Voltage Relaxation Spectroscopy (DOVRS) is an improved version of the formerly proposed Oxide Voltage Relaxation Spectroscopy (OVRS) technique which applies a periodic long duration constant current for tunneling injection. It has been demonstrated that the new technique can be used not only to separate and identify the oxide trap from interface trap, but also to separate and determine the centroid from the oxide trap density generated in the MOS system by the tunneling current stress. In the pulse constant current mode, the OVRS measurement can be completed instead of using the double current-voltage technique. Thus the new method results in more accurate and quicker measurements of the oxide trap centroid. Analytical expressions for computing the paramaters of the interface and oxide traps are derived. The effect of the channel carrier mobility on the spectroscopy is also considered. Two types of oxide and two types of interface traps were observed at a pulse constant Fowler-Nordheim current stress by the new method of DOVRS     

The preparation and magnetic properties of Fe-Ag granular solid using a sol-gel method

The Fe-Ag granular metal solid samples with 10% and 30% weight iron have been successfully fabricated using a sol-gel method, which are characterized by X-ray diffraction and transmission electron micrography. The average diameters of iron particles are from about a few nanometres to a few tens of nanometres controlled by the reducing temperature. The evolution of magnetic properties and microstructure during heat treating are described in detail and explained by using the superparamagnetism, single domain and multi domain theories. The magnetic anisotropy of the Fe-Ag granular solid is studied by using the law of approach to saturation. It is found that the magnetic anisotropy constant is in the order of 10⁵ J m^–3 which is higher than the value of the bulk iron and increases with the increase of reducing temperature.     

The influence of the alloying elements upon the transformation kinetics and morphologies of ferrite plates in alloy steels

A series of Fe-C-X and Fe-C-X₁-X₂ alloys in which X, X₁ and X₂ either raise or depress the activity of C iny were investigated by autodilatometer, optical microscopy, and transmission electron microscopy (TEM) to reveal the relations among the chemical composition, transformation kinetics, and morphology of ferrite plates. The incubation time of austenite decomposition at the nose temperature in the time-temperature-transformation (TTT) diagrams, the concentration of C in y in contact with theα/gg boundary, and the growth rate of ferrite were evaluated to estimate the magnitude of the solute drag-like effect (SDLE) for the different alloying elements used. All the results are consistent qualitatively with the SDLE hypothesis. This article is based on a presentation made at the Pacific Rim Conference on the “Roles of Shear and Diffusion in the Formation of Plate-Shaped Transformation Products,” held December 18-22, 1992, in Kona, Hawaii, under the auspices of ASM INTERNATIONAL’S Phase Transformations Committee.